The M+G+R Foundation
Understanding Its Mechanism
Role That D-Ribose Plays In Its Cure
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primary purpose of this brief note is our attempt
to present the mechanism that leads to Chronic Fatigue Syndrome, and
possible causes, in an easily to read and understand format.(0)
the principal causes of Chronic Fatigue Syndrome is the poor
functioning of the human organism at the cellular level [see below
Nutrition plays a critical role in maintaining healthy body starting at the cellular
level, and numerous
physiological deficiencies [the processing of nutrients] may contribute
to the poor functioning of the human cells, thus, the overall body.
The secondary purpose of this brief note is
to assist those interested in understanding why
D-Ribose is considered as a key (quasi magic) solution of Chronic
Syndrome, while, at the same time, help illustrate why, in some cases,
not work as expected.
Fatigue Syndrome (CFS)
fatigue syndrome (CFS) is the most common name
given to a variable debilitating disorder or disorders generally
persistent fatigue unrelated to exertion, not substantially relieved by
and accompanied by the presence of other specific symptoms for a
minimum of six
ADP and ATP
those acronyms must be used to
discuss CFS it will be best if we clearly define them first.
AMP- Adenosine Mono phosphate
ADP - Adenosine Di phosphate ; and
ATP - Adenosine
only difference is the number of phosphate (PO4)
groups in the Adenosine chain.
a chain of three phosphates (PO4) which are unstable. The removal of
the third phosphate triggers
the release of usable-by-the-body energy. Everything that a cell
up ATP, which, in the process, turns into ADP, which, in turn, and has
to be re-generated back into ATP. The vast
majority of ATP regeneration process happens in the mitochondria.
the root molecule to which the phosphate groups (PO4) are attached, is
composed of the base adenine and
the sugar D-Ribose.
biology, a mitochondrion (plural mitochondria)
is a membrane-enclosed organelle found in most eukaryotic cells (2)
are where oxygen and food are converted to energy. However, they
serve secondary functions as well.
For instance, when a cell is
the mitochondria release certain signals that trigger the death of the
cell. Mitochondria are inherited from the mother, so different
different mitochondria. Some are more efficient than others, and
people with less efficient
mitochondria have to learn what nutrients work best for them, and make
have enough of them.
In plain English: A mitochondrion is like a mini-cell inside every
which plays a key role in the restoration of the ATP once the
energy has been generated. It is also very complex, and must be
It can be simplified as
Stored energy + ATP => Usable energy for a
bodily process + ADP
ADP + Oxygen and Fuel
mitochondria) => ATP +
inert by products
[The reader may scroll down to The Dysfunction and skip the
following technical discussion without losing the thread of the
If ATP resources, for whatever reason,
are converted too far into ADP
too little ATP remains
available, some ATP can be
generated from the excess ADP
transferring one phosphate (PO4) from one ADP molecule to another.
"D" of "ADP" means two
(PO4); "T" of "ATP" means three (PO4) and
"M" of "AMP" means one,
therefore what the above equation represents is:
+ (PO4)(PO4) => (PO4)(PO4)(PO4) + (PO4)
(PO4) lost or gained - just rearranged among the molecules.
AMP can be regenerated back to ATP but it
is mostly lost. Therefore the AMP
to ATP emergency process
results in depletion
of the root molecule Adenosine from the cellular pool.
The cell can generate new Adenosine to increase the ADP/ATP
inventory in the cell, but it does
so very slowly because its key raw material is D-Ribose and the
only produce D-Ribose from glucose very, very slowly.
Fatigue Syndrome is caused by the inability of the body to change
into energy usable by
the body. Using a very easy to understand parallel: The engine
automobile cannot move the auto even if the fuel tank
full if it cannot convert the stored energy (gas in the tank) into
usable energy (motion).
Applying some basic logic, the CFS could be
caused, among other reasons, by:
function, so ATP is not generated at a sufficient pace to support an
Insufficiency of certain vitamins or minerals
required for proper mitochondrial function
Genetically inherited mitochondrial weakness (which may or may
not be addressed by supplementing a key factor).
Toxic exposure that has damaged mitochondria, in
which case recovery may be slow (and may be improved with proper
ATP/ADP pools in the cell have been depleted for some known or unknown
there is just not enough adenosine to regenerate them. Remember,
D-Ribose is a
component of Adenosine, and is produced by the body only slowly.
As it has
aptly expressed (4d):
CFS is different, we all have a different disease so to speak, some
toxic damage, some have more stress related adrenal damage, some have
immune system damage, and some have more central nervous system or
Damages due to natural human responses, primarily stress, have a
"responsible chemical" which may negatively affect the human cells.
emotion has a chemical consequence/reponse, for example - the immediate
discharge of adrenaline into the bloodstream in a moment of fight or
However, if that same life saving adrenaline is kept at a higher than
level in our system due to psychological disorders, it will stress our
bodies, thus our cells, the mitochondria in particular.
Even love triggers
chemical reactions throughout the human body which
many of its parts - brain included.
Proper nutrition is very important to keep
the mitochondria healthy, and with them, our cells well supplied with
keeps the body healthy overall. Unfortunately, and generally speaking,
do not eat well, and
sometimes lead to the problems listed above.
first to eat
well, but secondly, they should also experiment with simple supplements
to see which
restore our energy best. D-Ribose is one such candidate. (4)
most of the documents that we have reviewed on this subject matter -
even those authored by professionals - were presented in an obtuse and
incomplete manner [included some of those we cite in the footnote
no. 4]. Thus, our desire to simplify and professionally explain what we
cover in this document for the benefit of all - without the intent of
selling a dietetic supplement or impress anyone with undefined and
unnecessary "fancy words".
(3) Keeping Mitochondria in Good Working Order
good, balanced diet is key to good health, you have always been
told. That is indeed true, and a big part of the reason is that
mitochondria require a lot of different nutrients to properly process
and turn it into usable energy.
"Burning calories" (oxidizing
the food) is more than just a figure of speech. The whole process
is a controlled fire, which cannot get out of hand or the cell
dies. For instance, many of the B-vitamins are important for
the proper functioning of the cells, and some people will find that
are enough to keep their energy levels up, that is, keep "the fire
going on a controlled fashion".
One factor that has gained a lot of
attention is D-Ribose, which is the focus here.
We neither endorse nor recommend the products marketed directly or
indirectly in any of the following addresses. We are merely providing a
list of documents from which we acquired some information regarding CFS
Published on September 29,
2010, in Honor
of the Great Archangels Michael, Gabriel and Raphael - European Union
Copyright 2010 - 2016 by The M+G+R
Foundation. All rights reserved. However, you
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